Aripiprazole and Acute Extrapyramidal Symptoms in Children and Adolescents: A Meta-Analysis
Identifieur interne : 000089 ( Main/Exploration ); précédent : 000088; suivant : 000090Aripiprazole and Acute Extrapyramidal Symptoms in Children and Adolescents: A Meta-Analysis
Auteurs : Chiara Bernagie [Belgique] ; Marina Danckaerts [Belgique] ; Martien Wampers [Belgique] ; Marc De Hert [Belgique]Source :
- CNS Drugs [ 1172-7047 ] ; 2016.
Abstract
Both the US FDA and the European Medicines Agency (EMA) have approved aripiprazole for use in adolescents for specific indications. Given the assumed favorable side-effect profile of aripiprazole, its use in children and adolescents has increased for both official and off-label indications (anxiety disorders, eating disorders, personality disorders). However, several cases of children and adolescents with new-onset extrapyramidal symptoms (EPS) after commencing treatment with aripiprazole have been reported, and a more systematic appraisal of this possible risk is lacking.
We conducted a systematic review and a meta-analysis to assess the evidence for acute EPS (acute dystonia, akathisia, Parkinsonism) associated with the use of aripiprazole in children and adolescents.
We searched the MEDLINE and Embase databases (2003–10 April 2016) for clinical trials in pediatric patients (aged 0–18 years) using the keywords ‘aripiprazole’ (regardless of the formulation) and ‘extrapyramidal symptoms’. We evaluated the abstracts of papers using the following exclusion criteria: (1) study design: case report, letter to the editor, editorial, or poster presentation data; (2) unrelated PICOS (population, intervention, comparators, outcomes, study) structure. We performed a meta-analysis, in which we used effect sizes with 95 % confidence intervals (CIs). To examine the homogeneity of the effect size distribution, we used a Q-statistic. When we observed heterogeneity in effect sizes, we assessed the possible influence of moderator variables (age and sex, mean dose, study duration, and method of measuring EPS incidence) and evaluated the suitability of either a fixed or a random model. Finally, we assessed the incidence of EPS in children and adolescents treated with aripiprazole compared with placebo.
An initial search via PubMed and Embase yielded 328 hits. A manual search of the reference lists of review papers revealed seven additional relevant articles. We included 41 studies, with 2114 pediatric patients, in the meta-analysis. For the analysis of the mean incidence of EPS, data were provided by 24 studies, with a total of 1446 pediatric patients. Meta-analysis revealed a mean EPS incidence of 17.1 % (95 % CI 0.128–0.223). In terms of the incidence of various extrapyramidal side effects, overall, no significant effects of age, sex, mean dose, study duration, or measuring method could be demonstrated. The side effects ‘EPS’, ‘parkinsonism’, and ‘tremor’ were significantly more common in children and adolescents treated with aripiprazole than in those treated with placebo.
Our meta-analysis provides evidence for a non-negligible incidence of acute EPS in children and adolescents treated with aripiprazole. Although the study has several limitations and further investigation is needed, these findings may help clinicians make more balanced treatment choices and more closely monitor the use of this drug in youth.
The online version of this article (doi:10.1007/s40263-016-0367-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s40263-016-0367-y
PubMed: 27395403
PubMed Central: 4996892
Affiliations:
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Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation></author><author><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Department of Child and Adolescent Psychiatry, UPC KU Leuven-Z.org KU Leuven, UPC KU Leuven campus Leuven, UZ Leuven campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, UPC KU Leuven-Z.org KU Leuven, UPC KU Leuven campus Leuven, UZ Leuven campus Gasthuisberg, Herestraat 49, 3000 Leuven</wicri:regionArea><placeName><region type="province" nuts="2">Province du Brabant flamand</region><settlement type="city">Louvain</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff 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xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurosciences, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Psychiatry, UPC KU Leuven-Z.org KU Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Psychiatry, UPC KU Leuven-Z.org KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author></analytic><series><title level="j">CNS Drugs</title><idno type="ISSN">1172-7047</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Both the US FDA and the European Medicines Agency (EMA) have approved aripiprazole for use in adolescents for specific indications. Given the assumed favorable side-effect profile of aripiprazole, its use in children and adolescents has increased for both official and off-label indications (anxiety disorders, eating disorders, personality disorders). However, several cases of children and adolescents with new-onset extrapyramidal symptoms (EPS) after commencing treatment with aripiprazole have been reported, and a more systematic appraisal of this possible risk is lacking.</p></sec><sec><title>Objective</title><p>We conducted a systematic review and a meta-analysis to assess the evidence for acute EPS (acute dystonia, akathisia, Parkinsonism) associated with the use of aripiprazole in children and adolescents.</p></sec><sec><title>Method</title><p>We searched the MEDLINE and Embase databases (2003–10 April 2016) for clinical trials in pediatric patients (aged 0–18 years) using the keywords ‘aripiprazole’ (regardless of the formulation) and ‘extrapyramidal symptoms’. We evaluated the abstracts of papers using the following exclusion criteria: (1) study design: case report, letter to the editor, editorial, or poster presentation data; (2) unrelated PICOS (population, intervention, comparators, outcomes, study) structure. We performed a meta-analysis, in which we used effect sizes with 95 % confidence intervals (CIs). To examine the homogeneity of the effect size distribution, we used a Q-statistic. When we observed heterogeneity in effect sizes, we assessed the possible influence of moderator variables (age and sex, mean dose, study duration, and method of measuring EPS incidence) and evaluated the suitability of either a fixed or a random model. Finally, we assessed the incidence of EPS in children and adolescents treated with aripiprazole compared with placebo.</p></sec><sec><title>Results</title><p>An initial search via PubMed and Embase yielded 328 hits. A manual search of the reference lists of review papers revealed seven additional relevant articles. We included 41 studies, with 2114 pediatric patients, in the meta-analysis. For the analysis of the mean incidence of EPS, data were provided by 24 studies, with a total of 1446 pediatric patients. Meta-analysis revealed a mean EPS incidence of 17.1 % (95 % CI 0.128–0.223). In terms of the incidence of various extrapyramidal side effects, overall, no significant effects of age, sex, mean dose, study duration, or measuring method could be demonstrated. The side effects ‘EPS’, ‘parkinsonism’, and ‘tremor’ were significantly more common in children and adolescents treated with aripiprazole than in those treated with placebo.</p></sec><sec><title>Conclusion</title><p>Our meta-analysis provides evidence for a non-negligible incidence of acute EPS in children and adolescents treated with aripiprazole. Although the study has several limitations and further investigation is needed, these findings may help clinicians make more balanced treatment choices and more closely monitor the use of this drug in youth.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s40263-016-0367-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ben Amor, L" uniqKey="Ben Amor L">L Ben Amor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, D" uniqKey="Cohen D">D Cohen</name></author><author><name sortKey="Bonnot, O" uniqKey="Bonnot O">O Bonnot</name></author><author><name sortKey="Bodeau, N" uniqKey="Bodeau N">N Bodeau</name></author><author><name sortKey="Consoli, A" uniqKey="Consoli A">A Consoli</name></author><author><name sortKey="Laurent, C" uniqKey="Laurent C">C Laurent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stahl, Sm" uniqKey="Stahl S">SM Stahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Correll, Cu" uniqKey="Correll C">CU Correll</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Hert, M" uniqKey="De Hert M">M De Hert</name></author><author><name sortKey="Dobbelaere, M" uniqKey="Dobbelaere M">M Dobbelaere</name></author><author><name sortKey="Sheridan, Em" uniqKey="Sheridan E">EM Sheridan</name></author><author><name sortKey="Cohen, D" uniqKey="Cohen D">D Cohen</name></author><author><name sortKey="Correll, Cu" uniqKey="Correll C">CU Correll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caroff, Sn" uniqKey="Caroff S">SN Caroff</name></author><author><name sortKey="Hurford, I" uniqKey="Hurford I">I Hurford</name></author><author><name sortKey="Lybrand, J" uniqKey="Lybrand J">J Lybrand</name></author><author><name sortKey="Campbell, Ec" uniqKey="Campbell E">EC Campbell</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Correll, Cu" uniqKey="Correll C">CU Correll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumra, S" uniqKey="Kumra S">S Kumra</name></author><author><name sortKey="Oberstar, Jv" uniqKey="Oberstar J">JV Oberstar</name></author><author><name sortKey="Sikich, L" uniqKey="Sikich L">L Sikich</name></author><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Mcclellan, Jm" uniqKey="Mcclellan J">JM McClellan</name></author><author><name sortKey="Vinogradov, S" uniqKey="Vinogradov S">S Vinogradov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leucht, S" uniqKey="Leucht S">S Leucht</name></author><author><name sortKey="Cipriani, A" uniqKey="Cipriani A">A Cipriani</name></author><author><name sortKey="Spineli, L" uniqKey="Spineli L">L Spineli</name></author><author><name sortKey="Mavridis, D" uniqKey="Mavridis D">D Mavridis</name></author><author><name sortKey="Orey, D" uniqKey="Orey D">D Örey</name></author><author><name sortKey="Richter, F" uniqKey="Richter F">F Richter</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Olfson, M" uniqKey="Olfson M">M Olfson</name></author><author><name sortKey="King, M" uniqKey="King M">M King</name></author><author><name sortKey="Schoenbaum, M" uniqKey="Schoenbaum M">M Schoenbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipsey, M" uniqKey="Lipsey M">M Lipsey</name></author><author><name sortKey="Wilson, D" uniqKey="Wilson D">D Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hedges, L" uniqKey="Hedges L">L Hedges</name></author><author><name sortKey="Olkin, I" uniqKey="Olkin I">I Olkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simpson, Gm" uniqKey="Simpson G">GM Simpson</name></author><author><name sortKey="Angus, Jw" uniqKey="Angus J">JW Angus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guy, W" uniqKey="Guy W">W Guy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chouinard, G" uniqKey="Chouinard G">G Chouinard</name></author><author><name sortKey="Ross Chouinard, A" uniqKey="Ross Chouinard A">A Ross-Chouinard</name></author><author><name sortKey="Annable, L" uniqKey="Annable L">L Annable</name></author><author><name sortKey="Jones, Bd" uniqKey="Jones B">BD Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnes, Tr" uniqKey="Barnes T">TR Barnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lingjaerde, O" uniqKey="Lingjaerde O">O Lingjaerde</name></author><author><name sortKey="Ahlfors, Ug" uniqKey="Ahlfors U">UG Ahlfors</name></author><author><name sortKey="Bech, P" uniqKey="Bech P">P Bech</name></author><author><name sortKey="Dencker, Sj" uniqKey="Dencker S">SJ Dencker</name></author><author><name sortKey="Elgen, K" uniqKey="Elgen K">K Elgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenhill, Ll" uniqKey="Greenhill L">LL Greenhill</name></author><author><name sortKey="Vitiello, B" uniqKey="Vitiello B">B Vitiello</name></author><author><name sortKey="Fisher, P" uniqKey="Fisher P">P Fisher</name></author><author><name sortKey="Levine, J" uniqKey="Levine J">J Levine</name></author><author><name sortKey="Davies, M" uniqKey="Davies M">M Davies</name></author><author><name sortKey="Abikoff, H" uniqKey="Abikoff H">H Abikoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Robb, A" uniqKey="Robb A">A Robb</name></author><author><name sortKey="Nyilas, M" uniqKey="Nyilas M">M Nyilas</name></author><author><name sortKey="Forbes, Ra" uniqKey="Forbes R">RA Forbes</name></author><author><name sortKey="Jin, N" uniqKey="Jin N">N Jin</name></author><author><name sortKey="Ivanova, S" uniqKey="Ivanova S">S Ivanova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Nyilas, M" uniqKey="Nyilas M">M Nyilas</name></author><author><name sortKey="Forbes, R" uniqKey="Forbes R">R Forbes</name></author><author><name sortKey="Mcquade, Rd" uniqKey="Mcquade R">RD McQuade</name></author><author><name sortKey="Jin, N" uniqKey="Jin N">N Jin</name></author><author><name sortKey="Iwamoto, T" uniqKey="Iwamoto T">T Iwamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Youngstrom, Ea" uniqKey="Youngstrom E">EA Youngstrom</name></author><author><name sortKey="Mcnamara, Nk" uniqKey="Mcnamara N">NK McNamara</name></author><author><name sortKey="Stansbrey, Rj" uniqKey="Stansbrey R">RJ Stansbrey</name></author><author><name sortKey="Wynbrandt, Jl" uniqKey="Wynbrandt J">JL Wynbrandt</name></author><author><name sortKey="Adegbite, C" uniqKey="Adegbite C">C Adegbite</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Correll, Cu" uniqKey="Correll C">CU Correll</name></author><author><name sortKey="Nyilas, M" uniqKey="Nyilas M">M Nyilas</name></author><author><name sortKey="Forbes, Ra" uniqKey="Forbes R">RA Forbes</name></author><author><name sortKey="Mcquade, Rd" uniqKey="Mcquade R">RD McQuade</name></author><author><name sortKey="Jin, N" uniqKey="Jin N">N Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marcus, Rn" uniqKey="Marcus R">RN Marcus</name></author><author><name sortKey="Owen, R" uniqKey="Owen R">R Owen</name></author><author><name sortKey="Kamen, L" uniqKey="Kamen L">L Kamen</name></author><author><name sortKey="Manos, G" uniqKey="Manos G">G Manos</name></author><author><name sortKey="Mcquade, Rd" uniqKey="Mcquade R">RD McQuade</name></author><author><name sortKey="Carson, Wh" uniqKey="Carson W">WH Carson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Owen, R" uniqKey="Owen R">R Owen</name></author><author><name sortKey="Sikich, L" uniqKey="Sikich L">L Sikich</name></author><author><name sortKey="Marcus, Rn" uniqKey="Marcus R">RN Marcus</name></author><author><name sortKey="Corey Lisle, P" uniqKey="Corey Lisle P">P Corey-Lisle</name></author><author><name sortKey="Manos, G" uniqKey="Manos G">G Manos</name></author><author><name sortKey="Mcquade, Rd" uniqKey="Mcquade R">RD McQuade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tramontina, S" uniqKey="Tramontina S">S Tramontina</name></author><author><name sortKey="Zeni, Cp" uniqKey="Zeni C">CP Zeni</name></author><author><name sortKey="Ketzer, C" uniqKey="Ketzer C">C Ketzer</name></author><author><name sortKey="Pheula, Gf" uniqKey="Pheula G">GF Pheula</name></author><author><name sortKey="Narvaez, J" uniqKey="Narvaez J">J Narvaez</name></author><author><name sortKey="Rohde, La" uniqKey="Rohde L">LA Rohde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, Hk" uniqKey="Yoo H">HK Yoo</name></author><author><name sortKey="Joung, Ys" uniqKey="Joung Y">YS Joung</name></author><author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name></author><author><name sortKey="Song, Dh" uniqKey="Song D">DH Song</name></author><author><name sortKey="Lee, Ys" uniqKey="Lee Y">YS Lee</name></author><author><name sortKey="Kim, Jw" uniqKey="Kim J">JW Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleiss, J" uniqKey="Fleiss J">J Fleiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Mcnamara, Nk" uniqKey="Mcnamara N">NK McNamara</name></author><author><name sortKey="Youngstrom, Ea" uniqKey="Youngstrom E">EA Youngstrom</name></author><author><name sortKey="Stansbrey, Rj" uniqKey="Stansbrey R">RJ Stansbrey</name></author><author><name sortKey="Frazier, Tw" uniqKey="Frazier T">TW Frazier</name></author><author><name sortKey="Lingler, J" uniqKey="Lingler J">J Lingler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bildik, T" uniqKey="Bildik T">T Bildik</name></author><author><name sortKey="Ozbaran, Nb" uniqKey="Ozbaran N">NB Ozbaran</name></author><author><name sortKey="Kose, S" uniqKey="Kose S">S Kose</name></author><author><name sortKey="Cetin, Sk" uniqKey="Cetin S">SK Cetin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woods, Sw" uniqKey="Woods S">SW Woods</name></author><author><name sortKey="Tully, Em" uniqKey="Tully E">EM Tully</name></author><author><name sortKey="Walsh, Bc" uniqKey="Walsh B">BC Walsh</name></author><author><name sortKey="Hawkins, Ka" uniqKey="Hawkins K">KA Hawkins</name></author><author><name sortKey="Callahan, Jl" uniqKey="Callahan J">JL Callahan</name></author><author><name sortKey="Cohen, Sj" uniqKey="Cohen S">SJ Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibson, Ap" uniqKey="Gibson A">AP Gibson</name></author><author><name sortKey="Crismon, Ml" uniqKey="Crismon M">ML Crismon</name></author><author><name sortKey="Mican, Lm" uniqKey="Mican L">LM Mican</name></author><author><name sortKey="Fischer, C" uniqKey="Fischer C">C Fischer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyon, Gj" uniqKey="Lyon G">GJ Lyon</name></author><author><name sortKey="Samar, S" uniqKey="Samar S">S Samar</name></author><author><name sortKey="Jummani, R" uniqKey="Jummani R">R Jummani</name></author><author><name sortKey="Nirsch, S" uniqKey="Nirsch S">S Nirsch</name></author><author><name sortKey="Spirgel, A" uniqKey="Spirgel A">A Spirgel</name></author><author><name sortKey="Goldman, R" uniqKey="Goldman R">R Goldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Correll, Cu" uniqKey="Correll C">CU Correll</name></author><author><name sortKey="Penzer, Jb" uniqKey="Penzer J">JB Penzer</name></author><author><name sortKey="Parikh, Uh" uniqKey="Parikh U">UH Parikh</name></author><author><name sortKey="Mughal, T" uniqKey="Mughal T">T Mughal</name></author><author><name sortKey="Javed, T" uniqKey="Javed T">T Javed</name></author><author><name sortKey="Carbon, M" uniqKey="Carbon M">M Carbon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pringsheim, T" uniqKey="Pringsheim T">T Pringsheim</name></author><author><name sortKey="Panagiotopoulos, C" uniqKey="Panagiotopoulos C">C Panagiotopoulos</name></author><author><name sortKey="Davidson, J" uniqKey="Davidson J">J Davidson</name></author><author><name sortKey="Ho, J" uniqKey="Ho J">J Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ching, H" uniqKey="Ching H">H Ching</name></author><author><name sortKey="Pringsheim, T" uniqKey="Pringsheim T">T Pringsheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memarzia, J" uniqKey="Memarzia J">J Memarzia</name></author><author><name sortKey="Tracey, D" uniqKey="Tracey D">D Tracey</name></author><author><name sortKey="Giaroli, G" uniqKey="Giaroli G">G Giaroli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name></author><author><name sortKey="Datta, Ss" uniqKey="Datta S">SS Datta</name></author><author><name sortKey="Wright, Sd" uniqKey="Wright S">SD Wright</name></author><author><name sortKey="Furtado, Va" uniqKey="Furtado V">VA Furtado</name></author><author><name sortKey="Russell, Ps" uniqKey="Russell P">PS Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, Hk" uniqKey="Yoo H">HK Yoo</name></author><author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name></author><author><name sortKey="Paik, Kw" uniqKey="Paik K">KW Paik</name></author><author><name sortKey="Choi, Sh" uniqKey="Choi S">SH Choi</name></author><author><name sortKey="Yoon, Sj" uniqKey="Yoon S">SJ Yoon</name></author><author><name sortKey="Kim, Je" uniqKey="Kim J">JE Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Argyriou, E" uniqKey="Argyriou E">E Argyriou</name></author><author><name sortKey="Petroggona, M" uniqKey="Petroggona M">M Petroggona</name></author><author><name sortKey="Charitaki, S" uniqKey="Charitaki S">S Charitaki</name></author><author><name sortKey="Belivanaki, M" uniqKey="Belivanaki M">M Belivanaki</name></author><author><name sortKey="Giannakopoulos, G" uniqKey="Giannakopoulos G">G Giannakopoulos</name></author><author><name sortKey="Kolaitis, G" uniqKey="Kolaitis G">G Kolaitis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphey, Tk" uniqKey="Murphey T">TK Murphey</name></author><author><name sortKey="Mutch, J" uniqKey="Mutch J">J Mutch</name></author><author><name sortKey="Reid, Jm" uniqKey="Reid J">JM Reid</name></author><author><name sortKey="Edge, Pj" uniqKey="Edge P">PJ Edge</name></author><author><name sortKey="Storch, Ea" uniqKey="Storch E">EA Storch</name></author><author><name sortKey="Bengtson, M" uniqKey="Bengtson M">M Bengtson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Kauffman, Re" uniqKey="Kauffman R">RE Kauffman</name></author><author><name sortKey="Sallee, Fr" uniqKey="Sallee F">FR Sallee</name></author><author><name sortKey="Carson, Wh" uniqKey="Carson W">WH Carson</name></author><author><name sortKey="Nyilas, M" uniqKey="Nyilas M">M Nyilas</name></author><author><name sortKey="Mallikaarjun, S" uniqKey="Mallikaarjun S">S Mallikaarjun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pringsheim, T" uniqKey="Pringsheim T">T Pringsheim</name></author><author><name sortKey="Doja, A" uniqKey="Doja A">A Doja</name></author><author><name sortKey="Belanger, S" uniqKey="Belanger S">S Belanger</name></author><author><name sortKey="Patten, S" uniqKey="Patten S">S Patten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barzman, Dh" uniqKey="Barzman D">DH Barzman</name></author><author><name sortKey="Delbello, Mp" uniqKey="Delbello M">MP DelBello</name></author><author><name sortKey="Kowatch, Ra" uniqKey="Kowatch R">RA Kowatch</name></author><author><name sortKey="Gernert, B" uniqKey="Gernert B">B Gernert</name></author><author><name sortKey="Fleck, De" uniqKey="Fleck D">DE Fleck</name></author><author><name sortKey="Pathak, S" uniqKey="Pathak S">S Pathak</name></author><author><name sortKey="Rappaport, K" uniqKey="Rappaport K">K Rappaport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bastiaens, L" uniqKey="Bastiaens L">L Bastiaens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biederman, J" uniqKey="Biederman J">J Biederman</name></author><author><name sortKey="Mcdonnell, Ma" uniqKey="Mcdonnell M">MA McDonnell</name></author><author><name sortKey="Wozniak, J" uniqKey="Wozniak J">J Wozniak</name></author><author><name sortKey="Spencer, T" uniqKey="Spencer T">T Spencer</name></author><author><name sortKey="Aleardi, M" uniqKey="Aleardi M">M Aleardi</name></author><author><name sortKey="Falzone, R" uniqKey="Falzone R">R Falzone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biederman, J" uniqKey="Biederman J">J Biederman</name></author><author><name sortKey="Mick, E" uniqKey="Mick E">E Mick</name></author><author><name sortKey="Spencer, T" uniqKey="Spencer T">T Spencer</name></author><author><name sortKey="Doyle, R" uniqKey="Doyle R">R Doyle</name></author><author><name sortKey="Joshi, G" uniqKey="Joshi G">G Joshi</name></author><author><name sortKey="Hammerness, P" uniqKey="Hammerness P">P Hammerness</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budman, C" uniqKey="Budman C">C Budman</name></author><author><name sortKey="Coffey, Bj" uniqKey="Coffey B">BJ Coffey</name></author><author><name sortKey="Shechter, R" uniqKey="Shechter R">R Shechter</name></author><author><name sortKey="Schrock, M" uniqKey="Schrock M">M Schrock</name></author><author><name sortKey="Wieland, N" uniqKey="Wieland N">N Wieland</name></author><author><name sortKey="Spirgel, A" uniqKey="Spirgel A">A Spirgel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ercan, Es" uniqKey="Ercan E">ES Ercan</name></author><author><name sortKey="Uysal, T" uniqKey="Uysal T">T Uysal</name></author><author><name sortKey="Ercan, E" uniqKey="Ercan E">E Ercan</name></author><author><name sortKey="Ardic, Ua" uniqKey="Ardic U">UA Ardic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erickson, Ca" uniqKey="Erickson C">CA Erickson</name></author><author><name sortKey="Stigler, Ka" uniqKey="Stigler K">KA Stigler</name></author><author><name sortKey="Wink, Lk" uniqKey="Wink L">LK Wink</name></author><author><name sortKey="Mullett, Je" uniqKey="Mullett J">JE Mullett</name></author><author><name sortKey="Kohn, A" uniqKey="Kohn A">A Kohn</name></author><author><name sortKey="Posey, Dj" uniqKey="Posey D">DJ Posey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Short, Ej" uniqKey="Short E">EJ Short</name></author><author><name sortKey="Leskovec, T" uniqKey="Leskovec T">T Leskovec</name></author><author><name sortKey="Townsend, Ld" uniqKey="Townsend L">LD Townsend</name></author><author><name sortKey="Demeter, Ca" uniqKey="Demeter C">CA Demeter</name></author><author><name sortKey="Mcnamara, Nk" uniqKey="Mcnamara N">NK McNamara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Kauffman, R" uniqKey="Kauffman R">R Kauffman</name></author><author><name sortKey="Sallee, Fr" uniqKey="Sallee F">FR Sallee</name></author><author><name sortKey="Salazar, De" uniqKey="Salazar D">DE Salazar</name></author><author><name sortKey="Sahasrabudhe, V" uniqKey="Sahasrabudhe V">V Sahasrabudhe</name></author><author><name sortKey="Kollia, G" uniqKey="Kollia G">G Kollia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuperman, S" uniqKey="Kuperman S">S Kuperman</name></author><author><name sortKey="Calarge, C" uniqKey="Calarge C">C Calarge</name></author><author><name sortKey="Kolar, A" uniqKey="Kolar A">A Kolar</name></author><author><name sortKey="Holman, T" uniqKey="Holman T">T Holman</name></author><author><name sortKey="Barnett, M" uniqKey="Barnett M">M Barnett</name></author><author><name sortKey="Perry, P" uniqKey="Perry P">P Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marcus, Rn" uniqKey="Marcus R">RN Marcus</name></author><author><name sortKey="Owen, R" uniqKey="Owen R">R Owen</name></author><author><name sortKey="Manos, G" uniqKey="Manos G">G Manos</name></author><author><name sortKey="Mankoski, R" uniqKey="Mankoski R">R Mankoski</name></author><author><name sortKey="Kamen, L" uniqKey="Kamen L">L Kamen</name></author><author><name sortKey="Mcquade, Rd" uniqKey="Mcquade R">RD McQuade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masi, G" uniqKey="Masi G">G Masi</name></author><author><name sortKey="Cosenza, A" uniqKey="Cosenza A">A Cosenza</name></author><author><name sortKey="Millepiedi, S" uniqKey="Millepiedi S">S Millepiedi</name></author><author><name sortKey="Muratori, F" uniqKey="Muratori F">F Muratori</name></author><author><name sortKey="Pari, C" uniqKey="Pari C">C Pari</name></author><author><name sortKey="Salvadori, F" uniqKey="Salvadori F">F Salvadori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramos Rios, R" uniqKey="Ramos Rios R">R Ramos-Rios</name></author><author><name sortKey="Gago Ageitos, Am" uniqKey="Gago Ageitos A">AM Gago-Ageitos</name></author><author><name sortKey="Vidal Millares, M" uniqKey="Vidal Millares M">M Vidal-Millares</name></author><author><name sortKey="Mazaira Castro, Ja" uniqKey="Mazaira Castro J">JA Mazaira-Castro</name></author><author><name sortKey="Dominguez Santos, Md" uniqKey="Dominguez Santos M">MD Dominguez-Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rani, Fa" uniqKey="Rani F">FA Rani</name></author><author><name sortKey="Byrne, Pj" uniqKey="Byrne P">PJ Byrne</name></author><author><name sortKey="Murray, Ml" uniqKey="Murray M">ML Murray</name></author><author><name sortKey="Carter, P" uniqKey="Carter P">P Carter</name></author><author><name sortKey="Wong, Ick" uniqKey="Wong I">ICK Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rugino, Ta" uniqKey="Rugino T">TA Rugino</name></author><author><name sortKey="Janvier, Ym" uniqKey="Janvier Y">YM Janvier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanna, E" uniqKey="Sanna E">E Sanna</name></author><author><name sortKey="Atzeni, Mg" uniqKey="Atzeni M">MG Atzeni</name></author><author><name sortKey="Melis, Gl" uniqKey="Melis G">GL Melis</name></author><author><name sortKey="Carucci, S" uniqKey="Carucci S">S Carucci</name></author><author><name sortKey="Zuddas, A" uniqKey="Zuddas A">A Zuddas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Pp" uniqKey="Singh P">PP Singh</name></author><author><name sortKey="Meshram, Gg" uniqKey="Meshram G">GG Meshram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stigler, Ka" uniqKey="Stigler K">KA Stigler</name></author><author><name sortKey="Diener, Jt" uniqKey="Diener J">JT Diener</name></author><author><name sortKey="Kohn, Ae" uniqKey="Kohn A">AE Kohn</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Erickson, Ca" uniqKey="Erickson C">CA Erickson</name></author><author><name sortKey="Posey, Dj" uniqKey="Posey D">DJ Posey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tramontina, S" uniqKey="Tramontina S">S Tramontina</name></author><author><name sortKey="Zeni, Cp" uniqKey="Zeni C">CP Zeni</name></author><author><name sortKey="Pheula, Gf" uniqKey="Pheula G">GF Pheula</name></author><author><name sortKey="Ketzer, C" uniqKey="Ketzer C">C Ketzer</name></author><author><name sortKey="Rohde, La" uniqKey="Rohde L">LA Rohde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valicenti Mcdermott, Mr" uniqKey="Valicenti Mcdermott M">MR Valicenti-McDermott</name></author><author><name sortKey="Demb, H" uniqKey="Demb H">H Demb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, Hk" uniqKey="Yoo H">HK Yoo</name></author><author><name sortKey="Choi, Sh" uniqKey="Choi S">SH Choi</name></author><author><name sortKey="Park, S" uniqKey="Park S">S Park</name></author><author><name sortKey="Wang, Hr" uniqKey="Wang H">HR Wang</name></author><author><name sortKey="Hong, Jp" uniqKey="Hong J">JP Hong</name></author><author><name sortKey="Kim, Cy" uniqKey="Kim C">CY Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chevreuil, C" uniqKey="Chevreuil C">C Chevreuil</name></author><author><name sortKey="Polard, E" uniqKey="Polard E">E Polard</name></author><author><name sortKey="Lemonnier, E" uniqKey="Lemonnier E">E Lemonnier</name></author><author><name sortKey="Guillemot, P" uniqKey="Guillemot P">P Guillemot</name></author><author><name sortKey="Bentue Ferrer, D" uniqKey="Bentue Ferrer D">D Bentué-Ferrer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doey, T" uniqKey="Doey T">T Doey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenaway, M" uniqKey="Greenaway M">M Greenaway</name></author><author><name sortKey="Elbe, D" uniqKey="Elbe D">D Elbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckinney, C" uniqKey="Mckinney C">C McKinney</name></author><author><name sortKey="Renk, K" uniqKey="Renk K">K Renk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carbon, M" uniqKey="Carbon M">M Carbon</name></author><author><name sortKey="Kapoor, S" uniqKey="Kapoor S">S Kapoor</name></author><author><name sortKey="Sheridan, E" uniqKey="Sheridan E">E Sheridan</name></author><author><name sortKey="Al Jadiri, A" uniqKey="Al Jadiri A">A Al-Jadiri</name></author><author><name sortKey="Azzo, S" uniqKey="Azzo S">S Azzo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findling, Rl" uniqKey="Findling R">RL Findling</name></author><author><name sortKey="Mankoski, R" uniqKey="Mankoski R">R Mankoski</name></author><author><name sortKey="Timko, K" uniqKey="Timko K">K Timko</name></author><author><name sortKey="Lears, K" uniqKey="Lears K">K Lears</name></author><author><name sortKey="Mccartney, T" uniqKey="Mccartney T">T McCartney</name></author><author><name sortKey="Mcquade, Rd" uniqKey="Mcquade R">RD McQuade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basgul, Ss" uniqKey="Basgul S">SS Basgul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masi, G" uniqKey="Masi G">G Masi</name></author><author><name sortKey="Gagliano, A" uniqKey="Gagliano A">A Gagliano</name></author><author><name sortKey="Siracusano, R" uniqKey="Siracusano R">R Siracusano</name></author><author><name sortKey="Berloffa, S" uniqKey="Berloffa S">S Berloffa</name></author><author><name sortKey="Calarese, T" uniqKey="Calarese T">T Calarese</name></author><author><name sortKey="Ilardo, G" uniqKey="Ilardo G">G Ilardo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budman, Cl" uniqKey="Budman C">CL Budman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guy, W" uniqKey="Guy W">W Guy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jadad, Ar" uniqKey="Jadad A">AR Jadad</name></author><author><name sortKey="Moore, Ra" uniqKey="Moore R">RA Moore</name></author><author><name sortKey="Carroll, D" uniqKey="Carroll D">D Carroll</name></author><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author><author><name sortKey="Reynolds, Dj" uniqKey="Reynolds D">DJ Reynolds</name></author><author><name sortKey="Gavaghan, Dj" uniqKey="Gavaghan D">DJ Gavaghan</name></author><author><name sortKey="Mcquay, Hj" uniqKey="Mcquay H">HJ McQuay</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gearing, Re" uniqKey="Gearing R">RE Gearing</name></author><author><name sortKey="Mian, Ia" uniqKey="Mian I">IA Mian</name></author><author><name sortKey="Barber, J" uniqKey="Barber J">J Barber</name></author><author><name sortKey="Ickowicz, A" uniqKey="Ickowicz A">A Ickowicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vassar, M" uniqKey="Vassar M">M Vassar</name></author><author><name sortKey="Holzmann, M" uniqKey="Holzmann M">M Holzmann</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Forbes, A" uniqKey="Forbes A">A Forbes</name></author><author><name sortKey="Griffiths, P" uniqKey="Griffiths P">P Griffiths</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Belgique</li></country><region><li>Province du Brabant flamand</li></region><settlement><li>Louvain</li></settlement></list><tree><country name="Belgique"><region name="Province du Brabant flamand"><name sortKey="Bernagie, Chiara" sort="Bernagie, Chiara" uniqKey="Bernagie C" first="Chiara" last="Bernagie">Chiara Bernagie</name></region><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name><name sortKey="Danckaerts, Marina" sort="Danckaerts, Marina" uniqKey="Danckaerts M" first="Marina" last="Danckaerts">Marina Danckaerts</name><name sortKey="De Hert, Marc" sort="De Hert, Marc" uniqKey="De Hert M" first="Marc" last="De Hert">Marc De Hert</name><name sortKey="De Hert, Marc" sort="De Hert, Marc" uniqKey="De Hert M" first="Marc" last="De Hert">Marc De Hert</name><name sortKey="Wampers, Martien" sort="Wampers, Martien" uniqKey="Wampers M" first="Martien" last="Wampers">Martien Wampers</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|étape= Exploration
|type= RBID
|clé= PMC:4996892
|texte= Aripiprazole and Acute Extrapyramidal Symptoms in Children and Adolescents: A Meta-Analysis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27395403" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a OpenAccessBelV2
| This area was generated with Dilib version V0.6.25. |  |